Design and analysis of a non-inferiority trial in a tropical disease

Vortrag von Dr. Marcel Wolbers

Datum: 04.05.18  Zeit: 15.15 - 17.00  Raum: ETH HG G 19.1

We present the design and analysis of a randomized non-inferiority trial in talaromycosis, a major cause of human immunodeficiency virus (HIV)–related death in South and Southeast Asia. The talk will present the entire history of the trial highlighting the importance of a close collaboration between clinicians and statisticians. Moreover, it will focus on several statistical topics which arose during the trial including the choice of the non-inferiority margin, the issue of non-proportional hazards, and joint modeling of longitudinal fungal counts and mortality.